ABC of Clinical Haematology (ABC Series) by Drew Provan

By Drew Provan

This moment variation of the ABC of medical Haematology is a finished and useful advisor to this vast ranging speciality, masking the haematological features of such parts as pathology, molecular technology, melanoma, and basic medication. this can be a brief quantity including chapters on all parts of haematology written through those who care for those ailments every day. The booklet offers descriptions of those illnesses and describes the pathways focused on prognosis and remedy. complete color is used all through this seriously illustrated ebook, utilizing medical fabric and textual content containers to emphasize key issues. now we have additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require large previous wisdom.

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Example text

These molecular abnormalities frequently occur as the result of chromosomal translocations or the loss of chromosomal material. In addition, activating mutations in genes regulating cellular proliferation, such as tyrosine kinase genes, are commonly identified. Malignant transformation of primitive cells with the capacity to develop into cells of the myeloid lineage results in acute myeloid leukaemia (AML), while acquired genetic abnormalities in lymphoid progenitors result in acute lymphoblastic leukaemia (ALL).

New England Journal of Medicine 2003; 349: 1421–30. O’Brien SG, Guilhot F, Larson RA et al. Interferon and low dose cytarabine compared with imatinib for newly diagnosed chronic phase chronic myeloid leukemia. New England Journal of Medicine 2003; 348: 994–1004. Sawyers C. Chronic myeloid leukemia. New England Journal of Medicine 1999; 340: 1330–40. CHAPTER 6 The Acute Leukaemias Mark Cook, Charles Craddock OVERVIEW • Acute leukaemias develop as a consequence of acquired genetic abnormalities in haemopoietic stem cells • Acute leukaemias can be subdivided into acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL) • AML and ALL both present with symptoms of bone marrow failure caused by anaemia, neutropenia or thrombocytopenia • Chromosomal (cytogenetic) abnormalities define different biological subgroups of AML and ALL • Patient age, cytogenetic classification and response to initial chemotherapy are important factors allowing risk stratification • Treatment of both ALL and AML is initially with myelosuppressive chemotherapy • Allogeneic stem cell transplantation is reserved for patients predicted to have a poor outcome with chemotherapy alone Acute leukaemia is a malignant disorder of white cells caused by a failure of normal differentiation of haemopoietic stem cells and progenitors into mature cells.

We thank Dr Ellie Nacheva for the fluorescence in situ hybridization image showing deletion of the long arm of chromosome 20. g. imatinib) the duration of chronic phase disease is much longer than with earlier therapy • TKIs are therefore the best initial therapy for CML • Allografting is currently reserved for patients who fail TKIs Chronic myeloid leukaemia (CML) is a clonal malignant myeloproliferative disorder believed to originate in a single abnormal haemopoietic stem cell. The progeny of this abnormal stem cell proliferate over months or years, so that, by the time the leukaemia is diagnosed, the bone marrow is grossly hypercellular and the number of leucocytes is greatly increased in the peripheral blood.

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