By Karsten Schrör
Written by means of a number one professional on Aspirin-related learn, this can be the main complete treatise at the pharmacological results and medical functions of 1 of the main winning medicines ever.
The textual content is written with a large viewers in brain, and to be effectively comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised version includes the most recent result of scientific and pharmacological learn on Acetylsalicylic acid, addressing the a number of pharmacological houses of this well-known drug with a balanced view on their translation into scientific perform, together with prevention from cardiovascular illnesses and colorectal cancer.
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Extra resources for Acetylsalicylic Acid
1 (Continued) Date Event 1967–1968 OBrien, Zucker, Weiss, and coworkers publish the ﬁrst mechanistic studies on the antiplatelet activity of aspirin. Daily doses of 75 mg cause an inhibition of platelet function over several days. According to his data, OBrien recommends a clinical trial with aspirin for thrombosis prevention in patients at elevated vascular risk. 1971 Sir John Vane detects the inhibition of prostaglandin synthesis by aspirin (and salicylate) and considers this as the mechanism of the anti-inﬂammatory action.
C. (1949) Aspirin in the treatment of vascular diseases. The Lancet, 2, 1172–1174. L. (1950) Acetylsalicylic acid, possible prevention of coronary thrombosis. Annals of Western Medicine and Surgery, 4, 95–99. 55 Miner, J. and Hoffhines, A. (2007) The discovery of aspirins antithrombotic effects. Texas Heart Institute Journal, 34, 179–186. L. (1953) Experiences with aspirin (acetylsalicylic acid) in the non-speciﬁc prophylaxis of coronary thrombosis. Mississippi Valley Medicinal Journal, 75, 38–40.
2 Determination of Salicylates Measurement of salicylates in biological ﬂuids, that is, mainly plasma and urine, is of interest for several purposes. The purpose also determines the selection of the method. Most frequent is the control of plasma levels to verify that the plasma concentrations are within the therapeutic range. Determination of plasma levels is also necessary in the case of intoxication and for controlling the efﬁcacy of detoxiﬁcation procedures. 6). Finally, measurements are of interest to study the pharmacokinetics of salicylates in research, in particular, drug metabolism and interactions.